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D8065

Sigma-Aldrich

Dephostatin

>98% (HPLC), solid

Synonym(e):

1,4-Dihydroxy-N-methyl-N-nitroso­aniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)­hydro­quinone

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About This Item

Empirische Formel (Hill-System):
C7H8N2O3
CAS-Nummer:
151606-30-3
Molekulargewicht:
168.15
MDL-Nummer:
MFCD00467665
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278389

Assay

>98% (HPLC)

Form

solid

Farbe

light yellow

Löslichkeit

DMSO: soluble 22 mg/mL
H2O: insoluble

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

CN(N=O)c1cc(O)ccc1O

Angaben zum Gen

human ... PTPRCAP(5790)

Biochem./physiol. Wirkung

CD45-associated protein tyrosine phosphatase inhibitor.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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A Hiroki et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 56(4), 179-185 (2002-07-12)
Et-3,4-dephostatin, a protein-tyrosine phosphatase (PTPase) inhibitor, potentiates insulin-dependent signal transduction and shows an antidiabetic effect in mice. However, it contains a nitrosamine moiety that is often mutagenic and carcinogenic. Therefore, we previously designed and synthesized methoxime-3,4-dephostatin as a nitrosamine-free analogue
K Umezawa
Advances in enzyme regulation, 37, 393-401 (1997-01-01)
We have isolated signal transduction inhibitors of low molecular weight from microorganisms and plants. Since inducers of differentiation and apoptosis may be developed as new anticancer agents, we have studied induction of differentiation and apoptosis in neoplastic cells by our
Gang Liu
Current medicinal chemistry, 10(15), 1407-1421 (2003-07-23)
Protein tyrosine phosphatase 1B (PTP1B) has been implicated as one of the key negative regulators of insulin and leptin signal transduction pathways. PTP1B deficient mice are more sensitive to insulin, and have improved glycemic control and resistance to diet-induced obesity
S Wakino et al.
The Journal of biological chemistry, 276(50), 47650-47657 (2001-10-13)
The cyclin-dependent kinase inhibitor p21(Cip1) is up-regulated in response to mitogenic stimulation in various cells. PPARgamma ligands troglitazone (TRO, 10 microm) and rosiglitazone (RSG, 10 microm) attenuated the induction of p21(Cip1) protein by platelet-derived growth factor (PDGF) and insulin without
Laurent Gaté et al.
Biochemical pharmacology, 65(10), 1611-1622 (2003-05-20)
Glutathione S-transferase pi (GSTpi; EC 2.5.1.18) has been shown recently to be a regulator of mitogen-activated protein kinases (MAPK). We have developed, by chronic exposure of HL60 cells to increasing concentrations of a peptidomimetic GSTpi inhibitor TLK199, a 10-fold resistant
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