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D5446

Sigma-Aldrich

7,8-Dihydroxyflavonhydrat

≥98% (HPLC)

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10 MG
80,60 €
50 MG
323,00 €

80,60 €

Versandbereit am07. April 2025Details

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10 MG
80,60 €
50 MG
323,00 €

About This Item

Empirische Formel (Hill-System):
C15H10O4 · xH2O
CAS-Nummer:
38183-03-8
Molekulargewicht:
254.24 (anhydrous basis)
EG-Nummer:
253-812-4
MDL-Nummer:
MFCD00006836
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329798806
NACRES:
NA.77

80,60 €

Versandbereit am07. April 2025Details

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Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Löslichkeit

DMSO: 24 mg/mL

Lagertemp.

room temp

SMILES String

Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

InChI

1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChIKey

COCYGNDCWFKTMF-UHFFFAOYSA-N

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Anwendung

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice[1][2] and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).[3]

Biochem./physiol. Wirkung

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension.[4] 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.[5]
7,8-Dihydroxyflavone is a selective TrkB receptor agonist
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
037M4733V
026M4735V
045M4718V
025M4726V
114M4740V

Die passende Version wird nicht angezeigt?

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Xiaojuan Liu et al.
Molecules (Basel, Switzerland), 25(4) (2020-02-23)
O-methylation of flavonoids is an important modification reaction that occurs in plants. O-methylation contributes to the structural diversity of flavonoids, which have several biological and pharmacological functions. In this study, an O-methyltransferase gene (CrOMT2) was isolated from the fruit peel
Vasorelaxing and antihypertensive effects of 7, 8-dihydroxyflavone
Huai R
American Journal of Hypertension, 27(5), 750-760 (2013)
Maria N Schultz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 346-354 (2020-08-21)
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene Ube3a The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected
Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem
Jang M, et al.
eLife, 8, e42156-e42156 (2019)
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang MS, et al.
The Journal of Experimental Medicine, 214(10), 2947-2966 (2017)
Alle zugehörigen Dokumente anzeigen

Fragen

  1. What are the recommended storage conditions for D5446 after reconstitution?

    1 Antwort

    1. Although there is no datasheet available for product D5446, there is information available for a product sharing the same CAS number from a different division. Below is the information found for product 506300 (7,8 Dihydroxyflavone):

      - Solubility: DMSO (100 mg/ml)
      - Storage: Protect from light, +2°C to +8°C
      - Do Not Freeze: Ok to freeze
      - Special Instructions: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

      This information will also apply for product D5446. There are additional notes stating the product is packaged under inert gas. Therefore, if storing, it would be best to leave no air space in the storage container if possible. If that is not possible, it would be best to store under either dry nitrogen or argon.

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