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D144

Sigma-Aldrich

DALDA

>96%, solid

Synonym(e):

[D-Arg2, Lys4]-Dermorphin-(1-4)-amide

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About This Item

Empirische Formel (Hill-System):
C30H44N8O6
CAS-Nummer:
118476-85-0
Molekulargewicht:
612.72
MDL-Nummer:
MFCD00144042
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24893439

Assay

>96%

Form

solid

Farbe

white

Lagertemp.

−20°C

SMILES String

NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O

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Amino Acid Sequence

Tyr-D-Arg-Phe-Lys-NH2

Biochem./physiol. Wirkung

Highly selective μ opioid receptor agonist.

Lagerklassenschlüssel

8B - Non-combustible corrosive hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Damien J Keating et al.
The Journal of physiology, 555(Pt 2), 489-502 (2004-01-16)
Before the preganglionic regulation of the adrenal medulla is established, hypoxia acts directly on the chromaffin cells to evoke the secretion of catecholamines. This direct action of hypoxia is suppressed by the gradual development of the preganglionic innervation and we
Guo-Min Zhao et al.
The Journal of pharmacology and experimental therapeutics, 302(1), 188-196 (2002-06-18)
Recent studies suggest that delta-opioid receptors play a role in the development of opioid tolerance and led us to hypothesize that highly selective mu-opioid agonists may produce less tolerance. H-2',6'-dimethyltyrosine-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA) has extraordinary selectivity for mu-receptors (K(i)(delta)/K(i)(mu) > 14,000). Daily
Yong Ben et al.
British journal of pharmacology, 143(8), 987-993 (2004-11-24)
Previously, we reported that H-2',6'-dimethyltyrosine [Dmt(1)]-d-Arg-Phe-Lys-NH(2) (DALDA), an analogue of the naturally occurring opioid peptide dermorphin, is a highly potent and selective mu receptor agonist with low cross-tolerance to morphine. In the present study, we investigated the effect of treating
Pal Riba et al.
Current medicinal chemistry, 9(1), 31-39 (2002-02-28)
The clinical effectiveness of morphine is limited by several side effects, including the development of tolerance and dependence. Most of these side effects are believed to be mediated by central opioid receptors; therefore, hydrophilic opioids, which don't cross the blood-brain
Claire L Neilan et al.
The Journal of pharmacology and experimental therapeutics, 306(2), 430-436 (2003-03-29)
The dermorphin-derived peptide [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt, 2',6'-dimethyltyrosine) labels mu-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt1]DALDA displayed a mechanism of action distinct from that of morphine, as evidenced by its insensitivity to antisense
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