C9033

β-Chlor-L-Alanin -hydrochlorid

Alanine aminotransferase inhibitor

• Synonym(e): (R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
• Empirische Formel (Hill-System): C₃H₆ClNO₂ · HCl
• CAS-Nummer: 51887-89-9
• Molekulargewicht: 160.00
• MDL-Nummer: MFCD00070398
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24278345
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic
• Assay: ≥98% (TLC)
• Form: powder
• mp (Schmelzpunkt): 205 °C
• Löslichkeit: water: 50 mg/mL, clear, colorless
• Lagertemp.: −20°C
• SMILES String: Cl[H].N[C@@H](CCl)C(O)=O
• InChI: 1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
• InChIKey: IENJPSDBNBGIEL-DKWTVANSSA-N

Beschreibung

Anwendung

β-Chloro-L-alanine hydrochloride has been used:

• as a substrate for screening tyrosine phenol lyase steady state kinetics[1]
• in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells[2]
• as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system[3]

Biochem./physiol. Wirkung

β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT).[4] Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.[5]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves