C8990

Sp-8-pCPT-cAMPS

≥98% (HPLC), solid

• Synonym(e): 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt
• Empirische Formel (Hill-System): C₁₆H₁₄ClN₅O₅PS₂Na
• CAS-Nummer: 129693-13-6
• Molekulargewicht: 509.86
• MDL-Nummer: MFCD04113743
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724452

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Verpackung: vial of 5 μmol
• Löslichkeit: H₂O: >1 mg/mL
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• SMILES String: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

Beschreibung

Allgemeine Beschreibung

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

Anwendung

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

Biochem./physiol. Wirkung

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.

Selective cAMP-dependent protein kinase (PKA) activator.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)