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C7934

Sigma-Aldrich

2-Chloro-N6-cyclopentyl-1-deazaadenosine

Synonym(e):

DCCA

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About This Item

Empirische Formel (Hill-System):
C16H21ClN4O4
CAS-Nummer:
113646-62-1
Molekulargewicht:
368.82
MDL-Nummer:
MFCD00055218
UNSPSC-Code:
12352204
PubChem Substanz-ID:
329775156

SMILES String

OCC1OC(C(O)C1O)n2cnc3c(NC4CCCC4)cc(Cl)nc23

InChI

1S/C16H21ClN4O4/c17-11-5-9(19-8-3-1-2-4-8)12-15(20-11)21(7-18-12)16-14(24)13(23)10(6-22)25-16/h5,7-8,10,13-14,16,22-24H,1-4,6H2,(H,19,20)

InChIKey

ZQSTWOIIMKNFPE-UHFFFAOYSA-N

Biochem./physiol. Wirkung

A selective A1 adenosine receptor agonist

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Bin Yu et al.
BMC genomics, 19(1), 478-478 (2018-06-20)
Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. Apoptosis proteins subcellular localization information is very important for understanding the mechanism of programmed cell death and the development of drugs. Therefore, the
Nam D Nguyen et al.
PLoS computational biology, 16(4), e1007677-e1007677 (2020-04-03)
The molecular mechanisms and functions in complex biological systems currently remain elusive. Recent high-throughput techniques, such as next-generation sequencing, have generated a wide variety of multiomics datasets that enable the identification of biological functions and mechanisms via multiple facets. However
C Cano et al.
The Journal of pharmacology and experimental therapeutics, 261(2), 660-668 (1992-05-01)
The subtype of adenosine receptor linked to cardiac prostacyclin (PGI2) synthesis, measured as immunoreactive 6-keto-PGF1 alpha, was investigated in the rabbit heart perfused with Krebs' buffer at 20 ml/min. Adenosine (6.4-50 nmol) decreased 6-keto-PGF1 alpha synthesis, coronary perfusion pressure (PP)
E A van Schaick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(6), 827-837 (1998-02-07)
In this study we investigated the relationship between the pharmacokinetics and the cardiovascular and electroencephalogram (EEG) effects of three adenosine agonists with differing lipophilicity. Conscious normotensive rats received either 600 microg/kg N6-(p-sulphophenyl) adenosine (SPA), 200 microg/kg N6-cyclopentyladenosine (CPA) or 600
Eduardo Pérez-Valera et al.
Scientific reports, 9(1), 6760-6760 (2019-05-03)
Bacterial genes responsible for resistance to antibiotic agents (ARG) are spread from livestock to soil through application of manure, threatening environmental and human health. We investigated the mechanisms of ARG dissemination and persistence to disentangle i) the influence of nutrients
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