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C5874

Sigma-Aldrich

Cidofovir hydrate

≥98% (HPLC), powder, viral DNA synthesis inhibitor

Synonym(e):

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC; Cidovir, HPMPC, Vistide

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About This Item

Empirische Formel (Hill-System):
C8H14N3O6P · xH2O
CAS-Nummer:
113852-37-2
Molekulargewicht:
279.19 (anhydrous basis)
MDL-Nummer:
MFCD17215968
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329775105
NACRES:
NA.77

product name

Cidofovir hydrate, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated
protect from light

Löslichkeit

deionized water: ≥5 mg/mL (warmed)

Lagertemp.

room temp

SMILES String

O.NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1

InChI

1S/C8H14N3O6P.H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);1H2/t6-;/m0./s1

InChIKey

KLJYJZIIJLYJNN-RGMNGODLSA-N

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Biochem./physiol. Wirkung

Selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301,H315

Gefahreneinstufungen

Acute Tox. 3 Oral - Skin Irrit. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Supelco

PHR1593

Ganciclovir

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Sigma-Aldrich

R9644

Ribavirin

Phosphonessigsäure 98%

Sigma-Aldrich

284270

Phosphonessigsäure

Poly(vinylpyrrolidon)-Jod-Komplex

Sigma-Aldrich

PVP1

Poly(vinylpyrrolidon)-Jod-Komplex

Acyclovir Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1254

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Chlorhexidin ≥99.5%

Sigma-Aldrich

282227

Chlorhexidin

Methylzellulose viscosity: 4,000 cP

Sigma-Aldrich

M0512

Methylzellulose

Ryan N Jennings et al.
Journal of virology, 88(24), 14040-14049 (2014-09-26)
CD8(+) T cell responses are critical to the control of replication and reactivation associated with gammaherpesvirus infection. Type I interferons (IFNs) have been shown to have direct and indirect roles in supporting CD8(+) T cell development and function during viral
Beatrice Mercorelli et al.
Antimicrobial agents and chemotherapy, 64(10) (2020-07-22)
Posaconazole (PCZ) is a clinically approved drug used predominantly for prophylaxis and salvage therapy of fungal infections. Here, we report its previously undescribed anti-human cytomegalovirus (HCMV) activity. By using antiviral assays, we demonstrated that PCZ, along with other azolic antifungals
Stephen D S McCarthy et al.
PLoS neglected tropical diseases, 10(1), e0004364-e0004364 (2016-01-12)
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult
Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.
Vinod E Nambudiri et al.
JAMA dermatology, 149(9), 1068-1070 (2013-07-05)
Joanna Jackowska et al.
Lasers in medical science, 34(7), 1433-1440 (2019-02-15)
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to
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