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Wichtige Dokumente
C4871
Anti-CTGF (181-195) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(e):
Anti-CCN2, Anti-Connective tissue growth factor precursor isoform 1, Anti-HCS24, Anti-IGFBP8
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Biologische Quelle
rabbit
Konjugat
unconjugated
Antikörperform
IgG fraction of antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
antigen ~38 kDa
Speziesreaktivität
human
Methode(n)
western blot: 1:500-1:2,000
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... CTGF(1490)
Allgemeine Beschreibung
Connective tissue growth factor (CTGF) is a secreted multimodular protein, which is an important cytokine, belonging to the CCN family of multifunctional factors.
Immunogen
synthetic peptide corresponding to amino acids 181-195 of human CTGF
Anwendung
Anti-CTGF (181-195) antibody produced in rabbit has been used in immunoblot assay to study the protein expression of cells and renal tissues. It is also suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem./physiol. Wirkung
Connective tissue growth factor (CTGF) is involved in several developmental regulatory processes of chondrogenesis, osteogenesis, and angiogenesis. It also has implications in various pathologcal processes, including, fibrosis, and tumorigenesis. Its gene expression is sensitive to DNA methylation. The methylation of the CTGF promoter is correlated with CTGF expression in ovarian cancer cells and may be involved in liver tumorigenesis. Its C-terminal domain plays a vital role in the S1P (sphingosine-1-phosphate)-induced endothelial cell migration.
Physikalische Form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Hao Zhang et al.
Molecular medicine reports, 9(6), 2138-2144 (2014-03-29)
Increasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) and its complications. Previous studies conducted by our group have indicated that high glucose levels may induce the demethylation process of the connective
Margaret Markiewicz et al.
Microcirculation (New York, N.Y. : 1994), 18(1), 1-11 (2010-12-21)
The primary objective of this study was to examine the potential interaction between S1P, a pleiotropic lipid mediator, and CTGF/CCN2, a secreted multimodular protein, in the process of endothelial cell migration. The secondary objective was to determine whether C- and
Francisco V Souza-Neto et al.
Antioxidants (Basel, Switzerland), 11(7) (2022-07-28)
We have evaluated cardiac function and fibrosis in infarcted male Wistar rats treated with MitoQ (50 mg/kg/day) or vehicle for 4 weeks. A cohort of patients admitted with a first episode of acute MI were also analyzed with cardiac magnetic
Siao-Syun Guan et al.
Scientific reports, 5, 14561-14561 (2015-10-10)
In this study, we investigated the role of ATP synthase subunit-β (ATP5b) in diabetic nephropathy. Histopathological changes, fibrosis, and protein expressions of α-smooth muscle actin (α-SMA), advanced glycation end-products (AGEs), and ATP5b were obviously observed in the kidneys of db/db
Christoph Buken et al.
Scientific reports, 9(1), 11882-11882 (2019-08-17)
The literature suggests morphological alterations and molecular biological changes within the cellular milieu of human cells, exposed to microgravity (µg), as many cell types assemble to multicellular spheroids (MCS). In this study we investigated juvenile normal human dermal fibroblasts (NHDF)
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