Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

B4558

Sigma-Aldrich

BW B70C

>98% (HPLC), solid

Synonym(e):

N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C17H17FN2O3
CAS-Nummer:
134470-38-5
Molekulargewicht:
316.33
MDL-Nummer:
MFCD00890868
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24278269
NACRES:
NA.77

Assay

>98% (HPLC)

Form

solid

Farbe

white

Löslichkeit

DMSO: soluble 22 mg/mL

Lagertemp.

2-8°C

SMILES String

CC(\C=C\c1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O

InChI

1S/C17H17FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-12,22H,1H3,(H2,19,21)/b6-5+

InChIKey

UAIYNMRLUHHRMF-AATRIKPKSA-N

Angaben zum Gen

human ... ALOX5AP(241)

Anwendung

BW B70C has been used as a 5-lipoxygenase inhibitor to study its effects on eryptosis in erythrocytes.

Biochem./physiol. Wirkung

BW B70C exhibits anti-inflammatory and anti-tumorigenic activities. It exhibits therapeutic effects against hepatocellular carcinoma. BW B70C plays a role in allergen-induced bronchoconstriction by reducing the allergic airway closure and glycoconjugate secretion.
Selective 5-lipoxygenase inhibitor.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

T J Morley et al.
Toxicology and applied pharmacology, 146(2), 299-308 (1997-11-05)
In a study of structure-activity relationship with drug-induced nephropathy two lipoxygenase inhibitors, the N-hydroxyurea derivative 70C ((E)-N-{3-[3-(4-fluorophenoxy) phenyl]-1-(R, S)-methylprop-2-enyl}-N-hydroxyurea) and the N-hydroxamic acid analogue 360C ((E)-N-{3-[3-(4-fluorophenoxy) phenyl]-1-(R, S)-methylprop-2-enyl}-N-hydroxamic acid), were administered to rats. 70C and 360C were dosed to female
M F Bureau et al.
European journal of pharmacology, 324(1), 89-98 (1997-04-11)
The interference of the 5-lipoxygenase inhibitor, BW B70C ((E)-N-(3-[3-(4-fluorophenoxy)phenyl]-1(R,S)-methyl prop-2-enyl)-N-hydroxyurea), with Escherichia coli lipopolysaccharide (endotoxin)-induced lung leucocyte sequestration and microvascular albumin exchanges was evaluated in the anaesthetised guinea-pig using radioactive tracers, in parallel to the effects on cell counts in
B Dugas
Allergie et immunologie, 32(7), 284-289 (2000-11-30)
The effect of Lyprinol was evaluated on LTB4-induced human monocytes (normal and allergic donors) activation. Peripheral blood normal monocyte-derived monocytes when stimulated by Interleukin-4 (IL-4) produced high amounts of leukotriene B4 (LTB4) through the activation of the 5-lipoxygenase pathway. Maximal
M Yeadon et al.
Pulmonary pharmacology, 8(1), 53-63 (1995-02-01)
A method has been established for measurement of tracheal secretions in anaesthetized, ventilated guinea-pigs. The upper trachea was cannulated and perfused with saline. The perfusate was analysed for protein using the Lowry assay and for glycoconjugates ('mucus') by a procedure
Dan-Dan Xiong et al.
Journal of translational medicine, 16(1), 220-220 (2018-08-11)
Circular RNAs (circRNAs) have received increasing attention in human tumor research. However, there are still a large number of unknown circRNAs that need to be deciphered. The aim of this study is to unearth novel circRNAs as well as their
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.