B1061

BN82002 hydrochloride

≥97% (HPLC), solid

• Synonym(e): 4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol
• Empirische Formel (Hill-System): C₁₉H₂₅N₃O₄ · xHCl
• CAS-Nummer: 396073-89-5
• Molekulargewicht: 359.42 (free base basis)
• MDL-Nummer: MFCD08276984
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724410

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: solid
• Farbe: tan
• Löslichkeit: DMSO: 10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C

Beschreibung

Biochem./physiol. Wirkung

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor.

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC₅₀ in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC₅₀ in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

Vorsicht

Hygroscopic.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)