A7252

Ajmalin

• Empirische Formel (Hill-System): C₂₀H₂₆N₂O₂
• CAS-Nummer: 4360-12-7
• Molekulargewicht: 326.43
• EG-Nummer: 224-439-4
• MDL-Nummer: MFCD00135652
• UNSPSC-Code: 41116107

Eigenschaften

• Lagertemp.: 2-8°C
• SMILES String: CCC1C(O)N2C3CC1C4C(O)C5(CC24)[C@H]3N(C)c6ccccc56

Beschreibung

Biochem./physiol. Wirkung

Indole alkaloid from Rauwolfia serpentina that is a Class Ia antiarrhythmia compound. It blocks sodium channels in skeletal and cardiac muscle and cardiac HERG potassium channels in the open state but not in the closed state. Ajmaline administered intravenously prolongs the atrioventricular (AV) conduction times in the heart and has been used diagnostically to detect AV block and other cardiac abnormalities.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves