A3537

5-Aminosalicylsäure

powder, ≥99%

• Synonym(e): 5-AS, 5-Amino-2-hydroxy-benzoesäure, Mesalazin
• Lineare Formel: H₂NC₆H₃-2-(OH)CO₂H
• CAS-Nummer: 89-57-6
• Molekulargewicht: 153.14
• Beilstein: 2090421
• EG-Nummer: 201-919-1
• MDL-Nummer: MFCD00007877
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24890780
• NACRES: NA.83

Eigenschaften

• product name: 5-Aminosalicylsäure, ≥99%
• Assay: ≥99%
• Form: powder
• Farbe: off-white to gray
• mp (Schmelzpunkt): 275-280 °C (dec.) (lit.)
• Löslichkeit: 1 M HCl: 50 mg/mL, clear, yellow to brown
• Lagertemp.: 2-8°C
• SMILES String: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• InChIKey: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Angaben zum Gen: human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

Beschreibung

Anwendung

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform

5-Aminosalicylsäure ist ein Peroxidasesubstrat, geeignet für den Einsatz in ELISA-Verfahren. Dieses Substrat bildet ein lösliches braunes Endprodukt, das spektralphotometrisch bei 450 nm ausgelesen werden kann. Die Reaktion kann mit 3 N NaOH gestoppt und bei 550 nm ausgelesen werden.

Biochem./physiol. Wirkung

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H317,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves