A1260

1-Adamantylamin -hydrochlorid

≥98% (TLC), powder, NMDA receptor antagonist

• Synonym(e): 1-Amino-adamantan -hydrochlorid, Amantadin -hydrochlorid, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amin -hydrochlorid
• Empirische Formel (Hill-System): C₁₀H₁₇N · HCl
• CAS-Nummer: 665-66-7
• Molekulargewicht: 187.71
• Beilstein: 4198854
• EG-Nummer: 211-560-2
• MDL-Nummer: MFCD00074723
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277882
• NACRES: NA.77

Eigenschaften

• product name: 1-Adamantylamin -hydrochlorid,
• Form: powder
• Löslichkeit: H₂O: 50 mg/mL; ethanol: soluble
• Ersteller: Endo
• SMILES String: Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
• InChI: 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
• InChIKey: WOLHOYHSEKDWQH-SOVZANNPSA-N

Beschreibung

Allgemeine Beschreibung

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Anwendung

Amantadine hydrochloride has been used:

• to determine its effectiveness in reducing surgery-induced cognitive impairment
• to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
• to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
• to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
• to determine the pathway of internalization

Biochem./physiol. Wirkung

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves