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Merck
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Dokumente

A0976

Sigma-Aldrich

Monoclonal Anti-Angiostatin antibody produced in mouse

clone 79735, purified immunoglobulin, lyophilized powder

Synonym(e):

Anti-Angiostatin Kringle 1-3

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About This Item

MDL-Nummer:
MFCD03792411
UNSPSC-Code:
12352203

Biologische Quelle

mouse

Rekombinant

expressed in E. coli

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

79735, monoclonal

Form

lyophilized powder

Mol-Gew.

antigen 38 kDa

Speziesreaktivität

human

Darf nicht reagieren mit

mouse

Methode(n)

western blot: 1-2 μg/mL

Isotyp

IgG2a

UniProt-Hinterlegungsnummer

P00747

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PLG(5340)

Allgemeine Beschreibung

Angiostatin is an internal proteolytic fragment of plasminogen that has at least three kringle domains. This protein fragment functions as an endogenous angiogenesis inhibitor, and can also block endothelial cell proliferation,. Furthermore, angiostatin can specifically inhibit the growth of metastatic tumor.
Monoclonal Anti-Angiostatin recognizes human angiostatin. This antibody also recognizes plasminogen but shows no cross-reactivity with recombinant mouse angiostatin.

Immunogen

recombinant human angiostatin kringle 1-3 expressed in E. coli.

Anwendung

Mouse monoclonal anti-angiostatin antibody can be used for western blot applications at 1-2 μg/mL.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

José Ángel Nicolás-Ávila et al.
STAR protocols, 2(1), 100286-100286 (2021-01-26)
Cardiac exophers are membrane-bound extracellular vesicles released by cardiomyocytes with varied content and an average diameter of 3.5 μm. Here, we provide a detailed protocol to enable the identification and purification of cardiomyocyte-derived exophers by using fluorescence-activated cell sorting for downstream
M S O'Reilly et al.
Cell, 79(2), 315-328 (1994-10-21)
The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory mechanism. In our animal model, a primary tumor inhibits its remote metastases. After tumor removal, metastases neovascularize and grow. When
Z Wu et al.
Biochemical and biophysical research communications, 236(3), 651-654 (1997-07-30)
Angiostatin, a 38 kDa internal fragment of plasminogen, is an antiangiogenic endothelial cell inhibitor. It regresses several primary and metastatic tumors in mice. To produce recombinant angiostatin for further structural and functional studies, the mouse angiostatin gene preceded by a
Y Cao et al.
The Journal of biological chemistry, 271(46), 29461-29467 (1996-11-15)
Recently we have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically blocks the growth of endothelial cells (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. , Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y.

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