A0401

Adrenocorticotropic Hormon-Fragment 4-10 human, Ratte

≥97% (HPLC)

• Synonym(e): ACTH4-10
• Empirische Formel (Hill-System): C₄₄H₅₉N₁₃O₁₀S
• CAS-Nummer: 4037-01-8
• Molekulargewicht: 962.09
• MDL-Nummer: MFCD00167482
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24890423
• NACRES: NA.26

Eigenschaften

• product name: Adrenocorticotropic Hormon-Fragment 4-10 human, Ratte, ≥97% (HPLC)
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white
• UniProt-Hinterlegungsnummer: P01189; P47866
• Lagertemp.: −20°C
• SMILES String: CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O
• InChI: 1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)
• InChIKey: HAAUASBAIUJHAN-UHFFFAOYSA-N
• Angaben zum Gen: human ... POMC(5443) ; rat ... Crhr2(64680)

Beschreibung

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Biochem./physiol. Wirkung

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sonstige Hinweise

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Qualität

Lacks adrenocorticotropic activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)