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Merck

A023

Sigma-Aldrich

2-(Methylthio)adenosine 5′-triphosphate tetrasodium salt hydrate

solid, ≥90%

Synonym(e):

2-MeSATP, 2-Methylthio-ATP tetrasodium salt hydrate

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About This Item

Empirische Formel (Hill-System):
C11H14N5Na4O13P3S · xH2O
Molekulargewicht:
641.20 (anhydrous basis)
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:

Assay

≥90%

Form

solid

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

H2O: 13 mg/mL (Solutions should be freshly prepared.)

εmax

15,100 at 274 nm
20,900 at 233.4 nm

Versandbedingung

dry ice

Lagertemp.

−70°C

SMILES String

[Na+].[Na+].[Na+].[Na+].CSc1nc(N)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C11H18N5O13P3S.4Na/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1

InChIKey

UEEFBRHXFDJPTA-KWIZKVQNSA-J

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Biochem./physiol. Wirkung

2-Methylthioadenosine triphosphate is a potent P2Y purinoceptor agonist.

Vorsicht

Hygroscopic.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

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Peter D J Thornton et al.
PloS one, 8(2), e40840-e40840 (2013-02-06)
The nature of synaptic transmission at functionally distinct synapses in intestinal reflex pathways has not been fully identified. In this study, we investigated whether transmission between interneurons in the descending inhibitory pathway is mediated by a purine acting at P2Y
R Preston Mason et al.
BMC pharmacology & toxicology, 14, 48-48 (2013-10-01)
Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebivolol-stimulated bioavailable NO are not fully understood. Using amperometric NO and peroxynitrite
Melanie J Ludlow et al.
Cell calcium, 44(6), 567-579 (2008-05-20)
The presence of five P2X-like genes (p2xA-E) in Dictyostelium suggests that nucleotides other than cAMP may act as extracellular signalling molecules in this model eukaryote. However, p2xA was found to have an exclusively intracellular localisation making it unclear whether Dictyostelium
G Burnstock et al.
British journal of pharmacology, 79(4), 907-913 (1983-08-01)
ATP, 2-chloro-ATP, 2-methylthio-ATP, and their unnatural L-enantiomers, were synthesized and their effects tested on the guinea-pig taenia coli and urinary bladder, and the stimulated frog ventricle. The potent P2-purinoceptor agonists, 2-chloro-ATP and 2-methylthio-ATP were, respectively, 30 and 200 times more
N J Cusack et al.
British journal of pharmacology, 75(2), 397-400 (1982-02-01)
Some 2-alkylthio derivatives of adenosine 5'-monophosphate (AMP), adenosine 5'-monophosphorothioate (AMPS) and adenosine 5'-triphosphate (ATP) were examined as inhibitors of human platelet aggregation. 2-Methylthio-AMP, 2-ethylthio-AMP, 2-(pentan-l-yl)thio-AMP, 2-ethylthio-AMPS, 2-methylthio-ATP and 2-ethylthio-ATP (100 microM) each inhibited aggregation induced by adenosine 5'-diphosphate (ADP) but

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