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Merck

21932

Sigma-Aldrich

5(6)-Carboxynaphthofluoreszein

BioReagent, suitable for fluorescence, ≥90% (HPLC)

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About This Item

Empirische Formel (Hill-System):
C29H16O7
CAS-Nummer:
Molekulargewicht:
476.43
UNSPSC-Code:
12352108
PubChem Substanz-ID:
NACRES:
NA.32

Produktlinie

BioReagent

Assay

≥90% (HPLC)

Form

solid

pKa 

7.6

Fluoreszenz

λex 512 nm; λem 567 nm (acid/neutral)
λex 598 nm; λem 668 nm (basic)

Eignung

suitable for fluorescence

SMILES String

OC(=O)c1ccc2c(c1)C(=O)OC23c4ccc5cc(O)ccc5c4Oc6c3ccc7cc(O)ccc67.OC(=O)c8ccc9C(=O)OC%10(c%11ccc%12cc(O)ccc%12c%11Oc%13c%10ccc%14cc(O)ccc%13%14)c9c8

InChI

1S/2C29H16O7/c30-17-4-6-19-14(11-17)1-9-23-25(19)35-26-20-7-5-18(31)12-15(20)2-10-24(26)29(23)22-8-3-16(27(32)33)13-21(22)28(34)36-29;30-17-4-7-19-14(11-17)2-9-22-25(19)35-26-20-8-5-18(31)12-15(20)3-10-23(26)29(22)24-13-16(27(32)33)1-6-21(24)28(34)36-29/h2*1-13,30-31H,(H,32,33)

InChIKey

ANUHNEJUELPITC-UHFFFAOYSA-N

Anwendung

5(6)-Carboxynaphthofluorescein (CNF) may be used as an intravesicular pH-sensitive probe for the detection of activity, selectivity and cooperativity of ion channels such as gramicidin A.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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D A Jankowska et al.
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A Song et al.
Analytical chemistry, 69(5), 863-867 (1997-03-01)
A fast and durable ratiometric pH microoptode that is highly accurate, precise, sensitive, reversible, and reproducible over the physiological ranges of pH, ionic strength, and temperature has been developed. The sensing site consists of 5 (and 6)-carboxynaphthofluorescein (CNF) entrapped in
M Ramanathan et al.
Biosensors & bioelectronics, 22(12), 3001-3007 (2007-02-03)
The aim of the present work is to develop an evanescence wave array biosensor exploiting the "kinetic" approach of enzymatic reaction and further detection of the reaction products via pH sensitive fluorophore reporter. To demonstrate the feasibility of this approach
Shannon G Klein et al.
Global change biology, 23(9), 3690-3703 (2017-04-09)
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