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02582

Sigma-Aldrich

4-Pyridoxolactone

≥98.5% (HPLC)

Synonym(e):

β-Pyracin, 4-Pyridoxinsäurelacton, 4-Pyridoxolacton, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-on

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About This Item

Empirische Formel (Hill-System):
C8H7NO3
CAS-Nummer:
4753-19-9
Molekulargewicht:
165.15
Beilstein:
140752
MDL-Nummer:
MFCD13179358
UNSPSC-Code:
12352205
PubChem Substanz-ID:
329747468
NACRES:
NA.79

Assay

≥98.5% (HPLC)
98.5-101.5% (T)

Form

powder

Methode(n)

HPLC: suitable

Farbe

white to light yellow

Lagertemp.

−20°C

SMILES String

O=C1OCC2=CN=C(C)C(O)=C21

InChI

1S/C8H7NO3/c1-4-7(10)6-5(2-9-4)3-12-8(6)11/h2,10H,3H2,1H3

InChIKey

HHPDVQLBYQFYFA-UHFFFAOYSA-N

Biochem./physiol. Wirkung

4-Pyridoxolactone is a bacterial oxidation metabolite of vitamin B6.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Z Bannur et al.
Clinical biochemistry, 47(6), 427-431 (2014-03-04)
Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and
Nana Yokochi et al.
The Journal of biological chemistry, 279(36), 37377-37384 (2004-07-01)
Microbacterium luteolum YK-1 has pyridoxine degradation pathway I. We have cloned the structural gene for the second step enzyme, pyridoxal 4-dehydrogenase. The gene consists of 1,026-bp nucleotides and encodes 342 amino acids. The enzyme was overexpressed under cold shock conditions
Junichi Funami et al.
Biochimica et biophysica acta, 1753(2), 234-239 (2005-10-18)
4-Pyridoxolactonase is involved in the degradation pathway for pyridoxine, a free form of vitamin B6. The gene (mlr6805) encoding the putative 4-pyridoxolactonase of nitrogen fixing symbiotic microorganism Mesorhizobium loti MAFF303099 has been identified based on the genome database. The gene
Saki Nishimura et al.
Journal of nutritional science and vitaminology, 54(1), 18-24 (2008-04-05)
A determination method for individual natural vitamin B(6) compounds was developed. The vitamin B(6) compounds were specifically converted into 4-pyridoxolactone (PAL), a highly fluorescent compound, through a combination of enzymatic reactions and HCl-hydrolysis. PAL was then determined by HPLC. Pyridoxal
P Edwards et al.
Clinica chimica acta; international journal of clinical chemistry, 190(1-2), 67-80 (1990-09-01)
The effects of increased intake of pyridoxine hydrochloride on plasma vitamin B6 metabolism within therapeutic limits (up to 800 mg/day) were investigated. Maximum plasma concentrations of pyridoxal phosphate were attained at relatively low intakes of pyridoxine hydrochloride. Two metabolism thought
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