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S4429

Sigma-Aldrich

Sulindac

meets USP testing specifications

Synonym(e):

(Z)-5-Fluor-2-methyl-1-[p-(methylsulfinyl)-benzyliden]-inden-3-essigsäure

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About This Item

Empirische Formel (Hill-System):
C20H17FO3S
CAS-Nummer:
38194-50-2
Molekulargewicht:
356.41
EG-Nummer:
253-819-2
MDL-Nummer:
MFCD00599589
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24899604
NACRES:
NA.21

Agentur

USP/NF
meets USP testing specifications

Qualitätsniveau

200

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O

InChI

1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChIKey

MLKXDPUZXIRXEP-MFOYZWKCSA-N

Angaben zum Gen

human ... ALB(213) , PTGS1(5742) , PTGS2(5743)

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Biochem./physiol. Wirkung

Nicht-steroid, entzündungshemmend; begünstigter COX-1-Inhibitor

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Analysenzertifikate (COA)

Lot/Batch Number
MKCJ6559
MKCG3281
MKCF0273
MKCC6957
MKBZ3851V

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N M Davies et al.
Clinical pharmacokinetics, 32(6), 437-459 (1997-06-01)
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the indene acetic acid class. The absorption of sulindac is rapid when given orally. Sulindac is reversibly metabolised to sulindac sulphide which has anti-inflammatory and analgesic properties and is irreversibly metabolised to
Stephen X Skapek et al.
Pediatric blood & cancer, 60(7), 1108-1112 (2013-01-03)
Desmoid fibromatosis (desmoid tumor, DT) is a soft tissue neoplasm prone to recurrence despite complete surgical resection. Numerous small retrospective reports suggest that non-cytotoxic chemotherapy using tamoxifen and sulindac may be effective for DT. We evaluated the safety and efficacy
Dessislava Mladenova et al.
Cell communication and signaling : CCS, 11, 73-73 (2013-10-03)
The non-steroidal anti-inflammatory drug (NSAID) sulindac has shown efficacy in preventing colorectal cancer. This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation. We have recently shown that
Caihua Zhu et al.
Stem cells (Dayton, Ohio), 30(10), 2065-2075 (2012-06-02)
Pharmacological targeting of breast cancer stem cells (CSCs) is highly promising for the treatment of breast cancer, as the small population of CSCs appears responsible for tumor initiation and progression and also for resistance to conventional treatment. Here we report
D E Duggan
Drug metabolism reviews, 12(2), 325-337 (1981-01-01)
Sulindac is a prodrug which, following absorption, rapidly attains a metabolic equilibrium with its active pharmacophore, the sulfide metabolite. At the level of the whole body, the reversible interconversion sulindac in equilibrium sulfide, and the differing distributional and excretory properties
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