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A115

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Amitriptylin-Metabolit, (±)-E-10-hydroxyliert-

analytical standard

Synonym(e):

(±)-(E)-5-[3-(Dimethylamino)-propyliden]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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About This Item

Empirische Formel (Hill-System):
C20H23NO
CAS-Nummer:
64520-05-4
Molekulargewicht:
293.40
MDL-Nummer:
MFCD00069200
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329770681
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

200

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white

mp (Schmelzpunkt)

97-99 °C

Löslichkeit

0.1 M HCl: soluble
H2O: insoluble
methanol: soluble

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

SMILES String

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

InChIKey

GHWBJXOKAFHZAI-SFQUDFHCSA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Metabolit von Amitriptylin, tricyclisches Antidepressivum; Chromatographie-Standard.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
FN10182301
FN06022219
FN04232005
FN04301906
FN12191701

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X H Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 28(2), 85-91 (1993-01-01)
The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitriptyline. Great interindividual
F Coudoré et al.
Cell biology and toxicology, 13(2), 131-137 (1997-02-01)
Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were
Determination of tricyclic antidepressants in body fluids and organ material by HPLC.
Wedy, et al.
Fresenius Journal of Analytical Chemistry, 332, 266-266 (1988)
P Baumann et al.
International clinical psychopharmacology, 1(2), 102-112 (1986-04-01)
A subgroup of 16 out of 30 endogenous depressive inpatients (cf. part I), treated for 3 weeks with 150 mg amitriptyline (AT) daily, participated in a pharmacogenetic study: all were phenotyped with debrisoquine and 3 of them with mephenytoin. Four
K Shimoda et al.
Journal of clinical psychopharmacology, 15(3), 175-181 (1995-06-01)
We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there
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