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Merck

97326

Supelco

Isosilybin A

analytical standard

Synonym(e):

(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxy-phenyl)-3-(hydroxymethyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-4-chromanon

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About This Item

Empirische Formel (Hill-System):
C25H22O10
CAS-Nummer:
Molekulargewicht:
482.44
UNSPSC-Code:
85151701
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥95.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Verunreinigungen

≤10.0% water

Anwendung(en)

food and beverages

Format

neat

SMILES String

COc1cc(ccc1O)[C@H]2Oc3ccc(cc3O[C@@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1

InChIKey

FDQAOULAVFHKBX-HKTJVKLFSA-N

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Allgemeine Beschreibung

Isosilybin A is a flavonolignan and one of the bioactive component available in silymarin, which is isolated from Silybum marianum. It is commonly used in the treatment of cirrhosis, hepatitis and prevents the liver from being exposed to toxic substances.

Anwendung

Isosilybin B may be used as an analytical reference standard for the determination of the analyte in compound preparations of Silybum marianum and Silybum miltiorrhiza using high-performance liquid chromatography with photo diode array detection and electrospray ionization-mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

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Simultaneous determination of abietane-type diterpenes, flavonolignans and phenolic compounds in compound preparations of Silybum marianum and Salvia miltiorrhiza by HPLC-DAD-ESI MS
Zhao Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38(3), 564-570 (2005)
Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography?electrospray tandem mass spectrometry
Lee.IJ, et al.
Journal of Chromatography A, 1116(1-2), 147-152 (2006)
Jiazeng Yang et al.
Metabolic engineering, 59, 44-52 (2020-02-01)
Silymarin extracted from milk thistle seeds, is used for treating hepatic diseases. Silybin and isosilybin are its main components, and synthesized from coupling of taxifolin and coniferyl alcohol. Here, the biosynthetic pathways of taxifolin and coniferyl alcohol were reconstructed in

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