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Merck

91403

Supelco

Isovaleryl-L-carnitin

analytical standard

Synonym(e):

(2R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium Inneres Salz, L-Carnitin-isovalerylester

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About This Item

Empirische Formel (Hill-System):
C12H23NO4
CAS-Nummer:
Molekulargewicht:
245.32
Beilstein:
5946880
UNSPSC-Code:
41116107
NACRES:
NB.21

Qualität

analytical standard

Qualitätsniveau

Assay

≥94.0% (HPLC)

Optische Aktivität

[α]/D -23.0±2.0°, c = 0.1 in H2O

Haltbarkeit

limited shelf life, expiry date on the label

Verunreinigungen

≤12% water (calculated from elemental analysis)

Anwendung(en)

clinical testing

Format

neat

Lagertemp.

2-8°C

SMILES String

C[N+](C)(C)C[C@H](OC(CC(C)C)=O)CC([O-])=O

InChI

1S/C12H23NO4/c1-9(2)6-12(16)17-10(7-11(14)15)8-13(3,4)5/h9-10H,6-8H2,1-5H3/t10-/m1/s1

InChIKey

IGQBPDJNUXPEMT-SNVBAGLBSA-N

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Allgemeine Beschreibung

Isovaleryl-L-carnitine belongs to the acylcarnitines class of compounds. Acyl-L-carnitines are mostly produced from L-carnitine, which plays an important role in fatty acid metabolic pathways. The functions and roles of acyl-L-carnitines in various tissues like brain, heart, and muscle continue to attract much interest, since a number of diseases caused by defects of mitochondrial transport are characterized by specific metabolic dysfunctions and depend on the physiological role of the affected carrier in intermediary metabolism.

Anwendung

Isovaleryl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques.

Empfohlene Produkte

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography?tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects
Peng M, et al.
Journal of Chromatography A, 1319(9), 97-106 (2013)
Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable
Matrix effect?corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine
Abe K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 468, 187-194 (2017)
Arif Yurdagul et al.
Cell metabolism, 31(3), 518-533 (2020-02-01)
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial

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