70442

1-Naphthol

≥98.0% (GC)

• Synonym(e): α-Naphthol, 1-Hydroxynaphthalin
• Lineare Formel: C₁₀H₇OH
• CAS-Nummer: 90-15-3
• Molekulargewicht: 144.17
• Beilstein: 1817321
• EG-Nummer: 201-969-4
• MDL-Nummer: MFCD00003930
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57652248

Eigenschaften

• Dampfdichte: 4.5 (120 °C, vs air)
• Dampfdruck: 1 mmHg ( 94 °C)
• Assay: ≥98.0% (GC)
• Selbstzündungstemp.: 1007 °F
• Expl.-Gr.: 5 %
• bp: 278-280 °C (lit.)
• mp (Schmelzpunkt): 94-96 °C (lit.); 94-96 °C
• SMILES String: Oc1cccc2ccccc12
• InChI: 1S/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11H
• InChIKey: KJCVRFUGPWSIIH-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP1A2(1544)

Beschreibung

Allgemeine Beschreibung

1-Naphthol is the hydroxyl derivative of naphthalene. It forms hydrogen bonded complexes with H₂O, CH₃OH, NH₃ and ND₃ in gas phase. Hydrogen-bond dissociation energy of these complexes has been evaluated. Its sorption by biochars (obtained from orange peels, having pyrolytic temperatures in the range of 150-700 °C and designated as OP150-OP700) has been studied. It has been identified as an impurity in the active pharmaceutical ingredient (API) of duloxetine hydrochloride.

Anwendung

1-Naphthol (Naphthalen-1-ol) may be used as a standard for the NMR, FT-IR and mass spectrometric characterization of impurities present in the Duloxetine Hydrochloride active pharmaceutical ingredient (API).

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS05,GHS09
• Signalwort: Danger
• H-Sätze: H302,H311,H315,H317,H318,H335,H371,H410
• P-Sätze: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1A - STOT SE 2 Oral - STOT SE 3
• Zielorgane: Kidney, Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): 257.0 °F - closed cup
• Flammpunkt (°C): 125 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves