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01130595

Xanthohumol

primary reference standard

Synonym(e):

(E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)-phenyl]-3-(4-hydroxyphenyl)-propenon, 2′,4,4′-Trihydroxy-6′-methoxy-3′-prenylchalcon

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About This Item

Empirische Formel (Hill-System):
C21H22O5
CAS-Nummer:
6754-58-1
Molekulargewicht:
354.40
MDL-Nummer:
MFCD00210576
UNSPSC-Code:
85151701
PubChem Substanz-ID:
329747218
NACRES:
NA.24

Qualität

primary reference standard

Haltbarkeit

limited shelf life, expiry date on the label

Hersteller/Markenname

HWI

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

food and beverages

SMILES String

COc1cc(O)c(C\C=C(/C)C)c(O)c1C(=O)\C=C\c2ccc(O)cc2

InChI

1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+

InChIKey

ORXQGKIUCDPEAJ-YRNVUSSQSA-N

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Allgemeine Beschreibung

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Anwendung

Referenzstandard für die Analyse von pflanzlichen Medizinprodukten.

Sonstige Hinweise

This compound is commonly found in plants of the genus: humulus

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
HWI00080-3
HWI00080-2
HWI00080-1
HWI00080-1
HWI00080

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Yongbo Liu et al.
Journal of experimental therapeutics & oncology, 10(1), 1-8 (2012-09-06)
Xanthohumol (XN), a prenylated chalcone present in hops exhibits anti-inflammatory, antioxidant and anticancer activity. In the present study we show that XN inhibits the proliferation of mouse lymphoma cells and IL-2 induced proliferation and cell cycle progression in mouse splenic
Pawel Zmora et al.
Archives of animal nutrition, 66(1), 66-71 (2012-03-09)
There is a great interest in reducing the methane emission from ruminants as one possible cause of global warming. The aim of the presented study was to determine the effects of xanthohumol, one of the hop (Humulus lupulus) phytofactors, on
Hiroshi Hirata et al.
PloS one, 7(11), e49415-e49415 (2012-11-21)
Xanthohumol is expected to be a potent anti-atherosclerotic agent due to its inhibition of cholesteryl ester transfer protein (CETP). In this study, we hypothesized that xanthohumol prevents atherosclerosis in vivo and used CETP-transgenic mice (CETP-Tg mice) to evaluate xanthohumol as
J Rudzitis-Auth et al.
Human reproduction (Oxford, England), 27(6), 1735-1744 (2012-03-27)
Xanthohumol is a prenylated flavonoid isolated from hops, which is known to act as a pleiotropic cancer chemopreventive agent owing to its anti-proliferative, anti-inflammatory and anti-angiogenic properties. In the present study, we analyzed, for the first time, whether this dietary
Ciska Wyns et al.
Molecular nutrition & food research, 56(11), 1688-1696 (2012-09-25)
The intracellular fate of xanthohumol (XN) from hops is an underexplored field in the research for the molecular mechanisms causing its wide range of effects in chemoprevention and gene expression involved in hepatic metabolism. We aimed to elucidate possible targets
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