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PC41

Sigma-Aldrich

Anti-Cathepsin B (Ab-3) Rabbit pAb

liquid, Calbiochem®

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.43

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

liquid

Enthält

≤0.1% sodium azide as preservative

Speziesreaktivität

human

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

do not freeze

Isotyp

IgG

Versandbedingung

wet ice

Lagertemp.

2-8°C

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

Anti-Cathepsin B (Ab-3), rabbit polyclonal, recognizes the ~43 kDa latent and ~31 kDa active forms of cathepsin B in breast carcinoma. It is validated for Western blotting and for paraffin sections.
Purified rabbit polyclonal antibody. Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B.
Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B in breast carcinoma tissues.

Immunogen

Human
purified human liver cathepsin B

Anwendung

Immunoblotting (1 µg/ml)

Paraffin Sections (2.5 µg/ml, trypsin pre-treatment required)

Verpackung

Please refer to vial label for lot-specific concentration.

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

In 0.05 M sodium phosphate buffer, 0.2% gelatin.

Hinweis zur Analyse

Positive Control
SK-HEP-1 concentrated conditioned medium or breast carcinoma tissue

Sonstige Hinweise

Antibody should be titrated for optimal results in individual systems.
Barrett, A.J. and Kirschke, H. 1981. Methods Enzymol.80, 535.
Chan, S.J., et al. Proc. Natl. Acad. Sci. USA83, 7721.
Barrett, A.J. 1987. Trends Biochem. Sci.12, 193.
Sloane, B.F. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 137.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Mehrnoosh Saghizadeh et al.
Investigative ophthalmology & visual science, 46(10), 3604-3615 (2005-09-28)
To identify proteinases and growth factors abnormally expressed in human corneas of donors with diabetic retinopathy (DR), additional to previously described matrix metalloproteinase (MMP)-10 and -3 and insulin-like growth factor (IGF)-I. RNA was isolated from 35 normal, diabetic, and DR
Yixing Wu et al.
Acta neuropathologica communications, 11(1), 132-132 (2023-08-15)
Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer's disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome, a genetic condition caused
Wenqian Fang et al.
Translational research : the journal of laboratory and clinical medicine, 222, 28-40 (2020-05-22)
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease characterized by fat accumulation and inflammation in liver. Yet, the mechanistic insight and diagnostic and therapeutic options of NASH remain incompletely understood. This study tested the roles of
Xian Zhang et al.
iScience, 19, 607-622 (2019-08-26)
Transforming growth factor beta (TGF-β) signaling contributes to tissue fibrosis. Here we demonstrate that TGF-β enhances CatS and CatK expression but reduces CatB and CatL expression in mouse kidney tubular epithelial cells (TECs). CatS- and CatK deficiency reduces TEC nuclear

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