PC165L
Anti-Opioid μ Receptor (384-398) Rabbit pAb
lyophilized, Calbiochem®
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
serum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized
Enthält nicht
preservative
Speziesreaktivität
rat
Hersteller/Markenname
Calbiochem®
Lagerbedingungen
OK to freeze
Isotyp
IgG
Versandbedingung
ambient
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
rat ... Oprm1(25601)
Allgemeine Beschreibung
Rabbit polyclonal antibody supplied as lyophilized, undiluted serum. Recognizes the ~44-45 kDa opioid µ receptor protein.
Recognizes the ~44-45 kDa opiod μ receptor in caudate putamen and the dorsal horn of the spinal cord.
This Anti-Opioid µ Receptor (384-398) Rabbit pAb is validated for use in Frozen Sections, Immunoblotting, IF, IP for the detection of Opioid µ Receptor (384-398).
Immunogen
Rat
a synthetic peptide corresponding to amino acids 384-398 of rat opioid µ receptor
Anwendung
Frozen Sections (1:500-1:1000, Cy3 technique; 1:3000-1:6000, HRP)
Immunoblotting (1:2000-1:2500; see application references)
Immunofluorescence (1:100-1:200)
Immunoprecipitation (see comments)
Immunoblotting (1:2000-1:2500; see application references)
Immunofluorescence (1:100-1:200)
Immunoprecipitation (see comments)
Warnhinweis
Toxicity: Highly Toxic (H)
Physikalische Form
Undiluted serum.
Rekonstituierung
Reconstitute the lyophilized antibody with 100 µl sterile distilled H₂O. Resulting reconstituted solution contains ≤0.1% sodium azide. Be careful to reconstitute the entire contents of the vial; during shipment and handling portions of the lyophilized pellet may have become dislodged and may not be in the bottom of the vial. Following reconstitution, aliquot and freeze (-20°C).
Hinweis zur Analyse
Positive Control
Rat caudate putamen or spinal cord (dorsal horn)
Rat caudate putamen or spinal cord (dorsal horn)
Sonstige Hinweise
The specificity was determined by immunolabeling of transfected cells, immunoblotting analysis, and immunoisolation studies. Antibody specificity was examined in the rat caudate putamen and dorsal horn of the spinal cord. Staining is completely eliminated by pre-treatment of antibody with immunogen peptide at a concentration of 10 µg/ml. This antibody has also been reported to work for immunopercipitation. Antibody should be titrated for optimal results in individual systems.
Zaki, P.A., et al. 1996. Annu. Rev. Pharmacol. Toxicol.36, 379.
Arvidsson, U., et al. 1995. J. Neurosci.15, 3328.
Kieffer, B.L. 1995. Cell. Mol. Neurobiol.15, 615-635.
Childers, S.R. 1991. Life Sci.48, 1991.
Arvidsson, U., et al. 1995. J. Neurosci.15, 3328.
Kieffer, B.L. 1995. Cell. Mol. Neurobiol.15, 615-635.
Childers, S.R. 1991. Life Sci.48, 1991.
Rechtliche Hinweise
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Heng Xu et al.
The Journal of pharmacology and experimental therapeutics, 315(1), 248-255 (2005-07-01)
A growing body of literature indicates that chronic morphine exposure alters the expression and function of cytoskeletal proteins in addition to the well established interactions between mu opioid receptors and G proteins. In the present study, we hypothesized that chronic
Belén Gago et al.
Journal of neuroscience research, 91(12), 1533-1540 (2013-09-17)
The peptides dynorphin and enkephalin modulate many physiological processes, such as motor activity and the control of mood and motivation. Their expression in the caudate putamen (CPu) is regulated by dopamine and opioid receptors. The current work was designed to
Heng Xu et al.
Synapse (New York, N.Y.), 61(3), 166-175 (2006-12-08)
Previous studies established that Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) and (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester (herkinorin) are fully efficacious mu-agonists. Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in cells that over express beta-arrestin. We hypothesized that chronic HERK
Alicia Rivera et al.
Cells, 11(1) (2022-01-12)
Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum have been poorly studied despite its key function in drug-related habit learning.
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