MABN838

Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1

clone 8D7.1, from mouse

• Synonym(e): Retinal Dehydrogenase 1, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 8D7.1, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_000680
• UniProt-Hinterlegungsnummer: P00352
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ALDH1A1(216)

Beschreibung

Allgemeine Beschreibung

Retinal dehydrogenase 1 (EC 1.2.1.36; UniProt P00352; also known as Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, ALDH-E1, ALHDII, RALDH 1, RalDH1) is encoded by the ALDH1A1 (also known as ALDC, ALDH1, PUMB1) gene (Gene ID 216) in human. ALDH1A1, ALDH1A2, and ALDH1A3 constitute the ALDH1A subfamily of aldehyde dehydrogenases that catalyze the oxidation of all-trans retinal and 9-cis retinal to all-trans retinoic acid and 9-cis retinoic acid, respectively. In addition to its role in detoxifing 4-hydroxy-2-nonenal (4-HNE) in the lens and cornea, ALDH1A1 is also involved in many other biological processes, including stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids.

Immunogen

Epitope: N-terminal

GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.

Anwendung

Research Category
Neurowissenschaft

Research Sub Category
Signalübertragung & Neurowissenschaft

This Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Retinal Dehydrogenase 1/ALDH1A1.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of human cerebellum tissue lysate.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in human testis tissue.

Qualität

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of HepG2 cell lysate.

Zielbeschreibung

~55 kDa observed

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1k antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable