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MAB10404

Sigma-Aldrich

Anti-Ghrelin Antibody, clone 1ML-1D7

ascites fluid, clone 1ML-1D7, from mouse

Synonym(e):

ghrelin/obestatin prepropeptide1, ghrelin/obestatin2, ghrelin, growth hormone secretagogue receptor ligand1, obestatin1, ghrelin/obestatin preprohormone, Motilin-related peptide2, ghrelin1, M46 protein3, Growth hormone secretagogue

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

1ML-1D7, monoclonal

Speziesreaktivität

mouse, human

Methode(n)

immunocytochemistry: suitable
western blot: suitable

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

NP_057446.1

UniProt-Hinterlegungsnummer

Q9UBU3

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GHRL(51738)

Allgemeine Beschreibung

Ghrelin is a 28 amino acids peptide with an essential n-octonayl modification at Serine 3. This peptide hormone is known as an endogenous ligand for the growth hormone secretagogue receptor and shares sequence similarity with the peptide hormone Motilin. Ghrelin displays pleotropic actions including growth hormone secretion, feeding behaviour and gastrointestinal motility. It is predominantly produced by enteroendocrine cells from the gastrointestinal tract, but has been shown to play a significant role in neurotrophy, particularly in the hippocampus, and appears to be essential for cognitive adaptation to changing environments and the process of learning.

Spezifität

This antibody recognizes Ghrelin at the N-terminus.

Immunogen

Linear Peptide corresponding to the N-terminus of human Ghrelin.

Anwendung

Detect Ghrelin using this Anti-Ghrelin Antibody, clone 1ML-1D7 validated for use in WB & IC.
Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ghrelin in A431 cells.

Qualität

Evaluated by Western Blot in mouse stomach tissue lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Ghrelin in 10 µg of mouse stomach tissue lysate.

Zielbeschreibung

13 kDa calculated and observed

Hinweis zur Analyse

Control
Mouse stomach tissue lysate

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

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Bing Li et al.
International journal of clinical and experimental pathology, 8(12), 15993-15999 (2016-02-18)
Maternal stress exerts long-lasting postnatal growth on offspring, which persist into adulthood. However, the effect of maternal stress on appetizing system has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in
Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model.
Paxton, BE; Alley, CL; Crow, JH; Burchette, J; Weiss, CR; Kraitchman, DL; Arepally, A; Kim, CY
Journal of Vascular and Interventional Radiology : Jvir null
Cindy Y Kok et al.
Gene therapy, 31(3-4), 165-174 (2024-01-05)
Ghrelin is commonly known as the 'hunger hormone' due to its role in stimulating food intake in humans. However, the roles of ghrelin extend beyond regulating hunger. Our aim was to investigate the ability of ghrelin to protect against hydrogen
Wei Wei et al.
Cell metabolism, 19(6), 927-940 (2014-05-06)
Orexin neuropeptides promote arousal, appetite, reward, and energy expenditure. However, whether orexin affects bone mass accrual is unknown. Here, we show that orexin functions centrally through orexin receptor 2 (OX2R) in the brain to enhance bone formation. OX2R null mice
Tiziana Napolitano et al.
Cells, 10(11) (2021-11-28)
Background: Although several approaches have revealed much about individual factors that regulate pancreatic development, we have yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription factor specifically expressed in pancreatic acinar cells, whose role in pancreas

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