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ABE601

Sigma-Aldrich

Anti-CPEB1 Antibody

from rabbit, purified by affinity chromatography

Synonym(e):

Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CEBP, hCPEB-1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

rat

Speziesreaktivität (Voraussage durch Homologie)

human (immunogen homology)

Methode(n)

western blot: suitable

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CPEB1(64506)

Allgemeine Beschreibung

Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1, CPEB1) is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region and is found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.

Spezifität

This antibody recognizes the N-terminus of CPEB1.

Immunogen

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human CPEB1.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
RNA-Stoffwechsel & Bindungsproteine
Detect Cytoplasmic polyadenylation element-binding protein 1 using this rabbit polyclonal antibody, Anti-CPEB1 Antibody validated for use in western blotting.

Qualität

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected CPEB1 in 15 µg of rat brain tissue lysate.

Zielbeschreibung

~65 kDa observed. Uniprot describes 2 isoforms at ~54 kDa, one isoform at ~62 kDa, and one isoform at ~63 kDa Uncharacterized bands may appear in some lysates.

Physikalische Form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Rat brain tissue lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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