8.51028

Bis-Boc-amino-oxyacetic acid

Novabiochem^®

• Synonym(e): Boc ₂-Aoa-OH
• Empirische Formel (Hill-System): C₁₂H₂₁NO₇ · xH₂O
• Molekulargewicht: 291.30 (anhydrous basis)
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥97% (TLC)
• Form: powder
• Eignung der Reaktion: reagent type: ligand
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

This reagent can be used to introduce a hydroxylamine functionality to N-terminal or side-chain amino groups. Hydroxylamine-labeled peptides prepared in this manner can be ligated in aqueous solution at pH 3.5 to aldehyde-containing peptides via oxime formation. This bis-protected derivative eliminates oligomer formation which can occur with mono-protected hydroxylamine reagents as a result of double acylation. Coupling of this derivative should be done using an OSu ester.

Literature references

^[1] J. C. Spetzler & T. Hoeg-Jensen (2001) J. Peptide Sci., 7, 537.

Verlinkung

Replaces: 01-63-0129

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb bis beige
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Reinheit (DC(CMA2)): ≥ 97 %
Wasser (K. F.): 3.0 - 8.0 %
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3