616458

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem, 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
• Empirische Formel (Hill-System): C₂₁H₂₁NO₄
• CAS-Nummer: 666729-57-3
• Molekulargewicht: 351.40
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: DMSO: 10 mg/mL; ethanol: 2 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC₅₀ = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC₅₀ = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC₅₀ = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Shimizu, T., et al. 2008. J. Med. Chem.51, 3326.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10-13 - German Storage Class 10 to 13