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553590

Sigma-Aldrich

Ratjadone A

InSolution, ≥95%, Synthetic

Synonym(e):

InSolution Ratjadone A, Synthetic, Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II

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About This Item

Empirische Formel (Hill-System):
C28H40O5
CAS-Nummer:
Molekulargewicht:
456.61
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

Assay

≥95% (HPLC)

Form

liquid

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

OK to freeze
protect from light

Löslichkeit

aqueous buffer: ≤100 μM
methanol: 20 mg/mL

Versandbedingung

wet ice

Lagertemp.

−70°C

InChI

1S/C28H40O5/c1-6-9-26-22(5)25(30)18-27(33-26)24(29)12-7-10-19(2)16-21(4)17-20(3)14-15-23-11-8-13-28(31)32-23/h6-10,12-15,17,21-27,29-30H,11,16,18H2,1-5H3/b9-6+,12-7+,15-14+,19-10+,20-17-/t21-,22+,23-,24-,25-,26+,27+/m1/s1

InChIKey

CAYGMWMWJUFODP-AYFTZVAISA-N

Allgemeine Beschreibung

A cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.
A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.

Biochem./physiol. Wirkung

Cell permeable: yes
Primary Target
nuclear export of LR-NES
Product does not compete with ATP.
Reversible: no
Target IC50: ≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Flammable (J)

Physikalische Form

A 5 µg/ml solution (2 µg in 400 µl) in methanol.

Rekonstituierung

Following initial thaw, aliquot and freeze (-70°C).

Sonstige Hinweise

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Köster, M., et al. 2003. Exp. Cell Res.286, 321.
Kalesse, M., et al. 2001. Chem biochem2, 709.
Gerth, K., et al. 1995. J. Antibiot.48, 973.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F

Flammpunkt (°C)

9.7 °C


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