528120

PIPER - CAS 213416-70-7 - Calbiochem

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA.

• Synonym(e): PIPER - CAS 213416-70-7 - Calbiochem, N,Nʹ- bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV, N,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
• Empirische Formel (Hill-System): C₃₈H₃₆N₄O₄
• CAS-Nummer: 213416-70-7
• Molekulargewicht: 612.72
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: dark purple
• Löslichkeit: 5% acetic acid: 50 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
human telomerase

Product does not compete with ATP.

Reversible: no

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Sonstige Hinweise

Han, H., et al. 1999. Biochemistry38, 6981.
Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable