5.05207

Mecamylamine Hydrochloride

• Synonym(e): Mecamylamine Hydrochloride, N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
• Empirische Formel (Hill-System): C₁₁H₂₁N · xHCl
• CAS-Nummer: 826-39-1
• Molekulargewicht: 167.29 (free base basis)
• MDL-Nummer: MFCD00151462
• UNSPSC-Code: 12352116
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 640 nM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: H₂O: 100 mM
• Lagertemp.: 2-8°C
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
• InChIKey: PKVZBNCYEICAQP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A potent, nonselective, and noncompetitive antagonist of nAChRs (IC₅₀ = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).

Biochem./physiol. Wirkung

Primary Target
nAChR

Reversible: yes

Warnhinweis

Toxicity: Toxic (F)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Harris, C., et al. 2013. Psychopharmacol.225, 291.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable