480001

NDSB-195

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

• Synonym(e): NDSB-195, Dimethylethylammoniumpropansulfonat
• Empirische Formel (Hill-System): C₇H₁₇NO₃S
• CAS-Nummer: 160255-06-1
• Molekulargewicht: 195.28
• UNSPSC-Code: 12611902
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (TLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: white
• Löslichkeit: water: soluble
• Versandbedingung: ambient
• Lagertemp.: 15-25°C

Beschreibung

Allgemeine Beschreibung

Ein nichtdetergentes Sulfobetain. Berichten zufolge verhindern sie die Proteinaggregation und erleichtern die Renaturierung von chemisch und thermisch denaturierten Proteinen. Zwitterionisch über einen weiten pH-Bereich. Keine starke Absorption im nahen UV-Bereich. Leicht durch Dialyse entfernbar.

Anwendung

• Protein stabilizer, NDSB-195, enhances the dynamics of the β4 -α2 loop of ubiquitin.: This research explores how NDSB-195 stabilizes proteins by enhancing the dynamics of the β4-α2 loop of ubiquitin, providing insights into its mechanism of action as a protein stabilizer (Wang et al., 2016).


• Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.: The study demonstrates the effectiveness of NDSB-195 in suppressing the oligomerization of problematic compounds, showcasing its utility in biochemical and pharmaceutical applications (Mizukoshi et al., 2015).


• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor.: This article discusses the interaction of NDSB-195 with acidic fibroblast growth factor, emphasizing its role in preventing protein aggregation during biochemical processes (Xiang et al., 2008).


• Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA.: The study uses NDSB-195 in the preparation and crystallization process, enhancing the stability and quality of the DNA-binding domain crystals for X-ray diffraction analysis (Suwa et al., 2008).

Warnhinweis

Toxizität: Reizstoff (B)

Sonstige Hinweise

Goldberg, M.E., et al. 1996. Folding &; Design 1, 21.
Vuillard, L., et al. 1995. Anal. Biochem. 230, 290.
Vuillard, L., et al. 1995. Biochem. J. 305, 337.
Vuillard, L., et al. 1994. FEBS Lett.353, 294.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3