407294

αA-Interferon, Human, Recombinant, E. coli

• Synonym(e): IFNA2A, IFNA2B, IFNA2C, rhIFN-αA
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (SDS-PAGE)
• Qualitätsniveau: 100
• Form: liquid
• Spezifische Aktivität: ≥2.8 x 10⁸ units/mg protein; ≥5 x 10⁶ units/mL
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles
• Methode(n): cell based assay: suitable
• NCBI-Hinterlegungsnummer: NM_000605.4
• UniProt-Hinterlegungsnummer: P01563
• Versandbedingung: wet ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... IFNA1(3340)

Beschreibung

Allgemeine Beschreibung

Note: 1 MU = 1,000,000 units.

Recombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential in chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.

Recombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential with chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer. NOTE: 1MU = 1,000,000 units.

Warnhinweis

Toxicity: Standard Handling (A)

Einheitendefinition

One unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.

Physikalische Form

In PBS containing 0.1% BSA.

Angaben zur Herstellung

Dilute only in buffers containing protein such as 0.1% BSA.

Rekonstituierung

Following initial thaw, aliquot and freeze (-70°C).

Sonstige Hinweise

Fujishima, H., et al. 1998. Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995. Drugs 50, 873.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable