370695

GW1929

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).

• Synonym(e): GW1929, PPAR Agonist V, PPARγ Agonist IV
• Empirische Formel (Hill-System): C₃₀H₂₉N₃O₄
• CAS-Nummer: 196808-24-9
• Molekulargewicht: 495.57
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Form: crystalline solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 100 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
• InChIKey: QTQMRBZOBKYXCG-MHZLTWQESA-N

Beschreibung

Allgemeine Beschreibung

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine PPARγ and 6.2 nM for human PPARγ in cell-based transactivation assays).

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).

Biochem./physiol. Wirkung

Cell permeable: no

EC50 = 13 nM as peroxisome proliferator-activated receptor γ (PPARγ) agonist for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays

Primary Target
Peroxisome proliferator-activated receptor γ (PPARγ) agonist

Product does not compete with ATP.

Reversible: no

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Han, S., et al. 2004. Clin. Cancer Res.10, 1911.
Willson, T.M., et al. 2000. J. Med. Chem.43, 527.
Brown, K.K., et al. 1999. Diabetes48, 1415.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1