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324788

Sigma-Aldrich

DAPK Inhibitor

The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK.

Synonym(e):

DAPK Inhibitor, (4 Z)-4-(3-Pyridylmethylene)-2-styryl-oxazol-5-one, Death-Associated Protein Kinase Inhibitor, (4Z)-4-(3-Pyridylmethylene)-2-styryl-oxazol-5-one, Death-Associated Protein Kinase Inhibitor

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About This Item

Empirische Formel (Hill-System):
C17H12N2O2
CAS-Nummer:
315694-89-4
Molekulargewicht:
276.29
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥95% (HPLC)

Form

solid

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

OK to freeze
protect from light

Farbe

yellow

Löslichkeit

DMSO: 25 mg/mL

Versandbedingung

ambient

Lagertemp.

2-8°C

InChI

1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+

InChIKey

GFGMISOSPOPSHN-QCTDOKRBSA-N

Allgemeine Beschreibung

An oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 µM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 µM.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Okamoto, M., et al. 2009. J. Med. Chem.52, 7323.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Fraser Thomas et al.
Molecular oncology, 14(6), 1268-1281 (2020-04-20)
Cross-linking of the B-cell receptor (BCR) induces transcriptional activation of immediate early genes (IEGs) including EGR1 and DUSP2 in chronic lymphocytic leukaemia (CLL). Here, we have shown that this transcriptional activation correlated with histone H3 threonine 6 and 11 phosphorylation.
Katsuya Onishi et al.
FEBS letters, 597(5), 643-656 (2023-02-02)
Stiffness of the extracellular matrix regulates various biological responses, but the response mechanisms are poorly understood. Here, we found that the nuclear diphosphorylated myosin regulatory light chain (2P-MRLC) is a critical mechanomediator that suppresses apoptosis in response to substrate stiffness.
Mariko Takahashi et al.
Nature immunology, 22(4), 485-496 (2021-03-27)
Evasion of host immunity is a hallmark of cancer; however, mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified death-associated protein kinase 3 (DAPK3) as a previously unrecognized driver

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