14-253-M
p38β2/SAPK2b2 Protein, active, 10 µg
Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.
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About This Item
UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32
Biologische Quelle
human
Qualitätsniveau
Mol-Gew.
Mw 71 kDa
Hersteller/Markenname
Upstate®
Methode(n)
activity assay: suitable (kinase)
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Allgemeine Beschreibung
N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6.
Product Source: full length human p38β2/SAPK2b2, expressed in E. coli.
Biochem./physiol. Wirkung
Protein Target: p38β2/SAPK2b2
Target Sub-Family: CMGC
Qualität
routinely evaluated by phosphorylation of myelin basic protein
Physikalische Form
Affinity chromatography on glutathione-agarose beads
Lagerung und Haltbarkeit
6 months at -20°C
Sonstige Hinweise
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Skin Sens. 1
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Analysenzertifikate (COA)
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A Cuenda et al.
The EMBO journal, 16(2), 295-305 (1997-01-15)
Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution, was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF)
A Cuenda et al.
FEBS letters, 364(2), 229-233 (1995-05-08)
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)
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