119137

CGS 21680 hydrochloride

≥96% (HPLC), solid, adenosine A2A receptor agonist, Calbiochem^®

• Synonym(e): Adenosin-A2A-Rezeptoragonist I, CGS 21680, Hydrochlorid, CGS-21680, CGS21680, 3-(4-(2-((6-Amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propansäure
• Empirische Formel (Hill-System): C₂₃H₂₉N₇O₆ · xHCl
• CAS-Nummer: 124182-57-6
• Molekulargewicht: 499.52 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• product name: Adenosin-A2A-Rezeptoragonist I, CGS 21680, Hydrochlorid,
• Assay: ≥96% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 100 mM
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
• InChIKey: PAOANWZGLPPROA-OFRRTHGGSA-N

Beschreibung

Allgemeine Beschreibung

CGS 21680 is a potent adenosine A2A receptors agonist (Ki = 27 nM) and xanthin derivative. CGS 21680 HCl exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Been, shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.

Verpackung

Verpackt unter inertem Gas

Warnhinweis

Toxizität: Standard-Handhabung (A)

Physikalische Form

Wird als Hydrochlorid-Salz bereitgestellt.

Rekonstituierung

Nach der Rekonstitution in Aliquote aufteilen und einfrieren (-20 °C). Stammlösungen sind bei -20 °C bis zu 3 Monate haltbar.

Sonstige Hinweise

The molecular weight of CGS 21680 Hydrochloride this compound is batch-specific due to variable water content. For batch-specific molecular weight information, please refer the vial label or the certificate of analysis. The provided molecular weight represents the baseline molecular weight without water.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable