07-574
Anti-CENP-A Antibody
Upstate®, from rabbit
Synonym(e):
Anti-CENP-A, Anti-CenH3
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
affinity purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Aufgereinigt durch
affinity chromatography
Speziesreaktivität
human
Hersteller/Markenname
Upstate®
Methode(n)
western blot: suitable
Isotyp
IgG
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... CENPA(1058)
Allgemeine Beschreibung
CENP-A is a variant version of histone H3 found only at centromeres.
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
Spezifität
Broad species cross-reactivity is predicted.
CENP-A
Immunogen
peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A
Anwendung
Research Category
Epigenetik & nukleäre Funktionen
Epigenetik & nukleäre Funktionen
Research Sub Category
Zellzyklus, DNA-Replikation & -Reparatur
Zellzyklus, DNA-Replikation & -Reparatur
Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.
Qualität
routinely evaluated by immunoblot in acid extracted histones from HeLa cells
Zielbeschreibung
17kDa
Verlinkung
Replaces: 04-205
Physikalische Form
ImmunoAffinity Purified
Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
Lagerung und Haltbarkeit
Stable for 1 year at 2 to 8ºC from date of receipt.
Hinweis zur Analyse
Control
Control Histones (from Hela cells) colcemid-treated or untreated
Control Histones (from Hela cells) colcemid-treated or untreated
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Analysenzertifikate (COA)
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Qubo Zhu et al.
The Journal of cell biology, 185(5), 827-839 (2009-06-03)
Telomeric repeat binding factor 1 (TRF1) is a component of the multiprotein complex "shelterin," which organizes the telomere into a high-order structure. TRF1 knockout embryos suffer from severe growth defects without apparent telomere dysfunction, suggesting an obligatory role for TRF1
CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells.
Athwal, RK; Walkiewicz, MP; Baek, S; Fu, S; Bui, M; Camps, J; Ried, T; Sung, MH; Dalal, Y
Epigenetics & Chromatin null
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.
Strub T, Giuliano S, Ye T, Bonet C, Keime C, Kobi D, Le Gras S, Cormont M, Ballotti R et al.
Oncogene null
Leonid Andronov et al.
Bioinformatics (Oxford, England), 34(17), 3004-3012 (2018-04-11)
Single-molecule localization microscopy (SMLM) can play an important role in integrated structural biology approaches to identify, localize and determine the 3D structure of cellular structures. While many tools exist for the 3D analysis and visualization of crystal or cryo-EM structures
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.
Roshan L Shrestha et al.
Journal of cell science, 136(10) (2023-05-02)
Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and human cells. Even though overexpression and mislocalization of
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