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07-189

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Anti-Notch 4 Antibody

Upstate®, from rabbit

Synonym(e):

Anti-INT3

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

mouse

Hersteller/Markenname

Upstate®

Methode(n)

western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_004557

UniProt-Hinterlegungsnummer

Q99466

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... NOTCH4(4855)

Spezifität

truncated, intracellular domain of Int3/Notch 4, possibly full-length Notch 4; does not cross-react with Notch 1, 2 or 3

Immunogen

His-tag fusion protein containing the carboxy-terminus of murine Notch 4

Anwendung

Anti-Notch 4 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Notch 4 & has been validated in WB.

Qualität

routinely evaluated by immunoblot on lysates from 293 cells transfected with the intracellular domain of murine Notch 4

Zielbeschreibung

68kDa

Physikalische Form

Format: Purified

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Ahmed Raafat et al.
Scientific reports, 7(1), 13690-13690 (2017-10-24)
Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the interaction of Int3 with the
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Sharon Bargo,Ahmed Raafat,David McCurdy,Idean Amirjazil,Youmin Shu,June Traicoff et al.
Biochemical and biophysical research communications null
Ahmed Raafat et al.
Journal of cellular physiology, 226(7), 1940-1952 (2011-04-21)
Notch genes play a critical role in mammary gland growth, development and tumorigenesis. In the present study, we have quantitatively determined the levels and mRNA expression patterns of the Notch receptor genes, their ligands and target genes in the postnatal
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.
Magnani, L; Stoeck, A; Zhang, X; Lanczky, A; Mirabella, AC; Wang, TL; Gyorffy, B; Lupien, M
Proceedings of the National Academy of Sciences of the USA null
S Zhang et al.
Oncogene, 35(19), 2485-2495 (2015-08-19)
Notch controls pancreatic differentiation during development and is reactivated in pancreatic cancer. In recent years, the importance of Notch signaling in pancreatic tumorigenesis has become increasingly evident; however, it remains unclear how Notch activities are regulated in this context. Here
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