07-1800
Anti-eIF4G Antibody
serum, from rabbit
Synonym(e):
eIF-4-gamma 1, eIF-4G 1, eukaryotic translation initiation factor 4 gamma 1
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
serum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Speziesreaktivität
human, mouse
Methode(n)
immunofluorescence: suitable
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... EIF4G1(1981)
Allgemeine Beschreibung
eIF4F is a translation initiation factor containing three subunits: eIF4A, eIF4E, and eIF4G. This complex is a key component in promoting ribosomal binding to the mRNA. eIF4G interacts with both eIF4A and eIF4E though its carboxy and amino terminal domains, respectively. eIF4E binds to the cap structure of the mRNA, while the ATP-dependent RNA helicase eIF4A unwinds the secondary structure of the 5’ UTR. eIF4G plays a critical role in coordinating the assembly of the eukaryotic initiation factors. It acts as a bridge to bind the cap-bound eIF4E, eIF4AI&II, the eIF3 complex, PABP1, and the kinase Mnk1 (Lejeune, F., et al., 2004) in a large eukaryotic initiation factor complex
Spezifität
Not tested on other species.
This antibody detects eIF4G at its N-terminal region.
Immunogen
Epitope: N-terminus
Synthetic peptide corresponding to N-terminal region of human eIF4G.
Anwendung
Research Category
Zelluläre Signaltransduktion
Zelluläre Signaltransduktion
Research Sub Category
RNA-Bindeproteine (RBP)
Insulin-/stoffwechselassoziierte Signalübertragung
RNA-Bindeproteine (RBP)
Insulin-/stoffwechselassoziierte Signalübertragung
Anti-eIF4G Antibody is an antibody against eIF4G for use in WB & IF.
Qualität
Evaluated by western blot on HeLa cytoplasmic extract.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
Zielbeschreibung
220 kDa
Physikalische Form
Rabbit polyclonal serum with 0.05% NaN3.
Lagerung und Haltbarkeit
Stable for 1 year at -20ºC from date of receipt.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
Analysenzertifikate (COA)
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