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Dokumente

N33101

Sigma-Aldrich

Norharman

98%

Synonym(e):

β-Carboline, 9H-Pyrido[3,4-b]indole

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About This Item

Empirische Formel (Hill-System):
C11H8N2
CAS-Nummer:
244-63-3
Molekulargewicht:
168.19
MDL-Nummer:
MFCD00004956
UNSPSC-Code:
12352202
PubChem Substanz-ID:
329818607

Assay

98%

SMILES String

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChIKey

AIFRHYZBTHREPW-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

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Andrés G León et al.
Journal of chromatography. A, 1192(2), 254-258 (2008-04-25)
The presence of cyclodextrins (CDs) in the mobile phase alters the chromatographic equilibria and induces a secondary chemical equilibrium associated to the chromatographic separation by HPLC. In this study the influence of the presence of CDs in the mobile phase
Rosa Busquets et al.
Molecular nutrition & food research, 53(12), 1496-1504 (2009-10-08)
Heterocyclic amines (HCAs) are potent mutagens/carcinogens to which humans are frequently exposed through the consumption of cooked meat and fish food. The effect of normal intake of HCAs and their role in the aetiology of human cancer is unknown. To
M Micaela Gonzalez et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 8(8), 1139-1149 (2009-07-30)
The photochemistry of norharmane (9H-pyrido[3,4-b]indole) in acidic (pH 5.0+/-0.1) and alkaline (pH 10.0+/-0.1) aqueous solutions was studied. The photochemical reactions were monitored by TLC, UV/VIS absorption spectroscopy, high-performance liquid chromatography (HPLC), electronic ionization-mass spectrometry (EI-MS), UV-laser desorption/ionization-time of flight-mass spectrometry
Olga I Tarzi et al.
Journal of mass spectrometry : JMS, 44(2), 260-277 (2008-11-18)
The thermal stability of several commonly used crystalline matrix-assisted ultraviolet laser desorption/ionization mass spectrometry (UV-MALDI-MS) matrices, 2,5-dihydroxybenzoic acid (gentisic acid; GA), 2,4,6-trihydroxyacetophenone (THA), alpha-cyano-4-hydroxycinnamic acid (CHC), 3,5-dimethoxy-4-hydroxycinnamic acid (sinapinic acid; SA), 9H-pirido[3,4-b]indole (nor-harmane; nor-Ho), 1-methyl-9H-pirido[3,4-b]indole (harmane; Ho), perchlorate of nor-harmanonium
Yoo Jung Yang et al.
European journal of pharmacology, 587(1-3), 57-64 (2008-05-07)
The effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Harman and norharman at a concentration of 20 microM and 100 microM showed 49.4% and 49.5% inhibition of dopamine content for 48 h
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