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H4392

Sigma-Aldrich

3-Hydroxy-3-methyl-glutarsäure

≥95%

Synonym(e):

3-Hydroxy-3-methylpentandionsäure

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About This Item

Lineare Formel:
HOC(CH3)(CH2CO2H)2
CAS-Nummer:
503-49-1
Molekulargewicht:
162.14
Beilstein:
1769194
EG-Nummer:
207-971-1
MDL-Nummer:
MFCD00002712
UNSPSC-Code:
12352100
PubChem Substanz-ID:
57654253
NACRES:
NA.22

Assay

≥95%

mp (Schmelzpunkt)

105-108 °C (lit.)

Lagertemp.

−20°C

SMILES String

CC(O)(CC(O)=O)CC(O)=O

InChI

1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)

InChIKey

NPOAOTPXWNWTSH-UHFFFAOYSA-N

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Anwendung

  • Improvement of the functional value of green soybean (edamame) using germination and tempe fermentation: A comparative metabolomics study.: This research enhances the functional value of green soybean through germination and fermentation, identifying metabolites including those derived from 3-Hydroxy-3-methylglutaric acid. It offers insights into food processing and nutritional biochemistry (Iman et al., 2023).

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Beatriz Puisac et al.
Journal of inherited metabolic disease, 33(4), 405-410 (2010-06-10)
3-Hydroxy-3-methylglutaric aciduria is a rare human autosomal recessive disorder caused by deficiency of 3-hydroxy-3-methylglutaryl CoA lyase (HL). This mitochondrial enzyme catalyzes the common final step of leucine degradation and ketogenesis. Acute symptoms include vomiting, seizures and lethargy, accompanied by metabolic
Mohamad Eid Hammadeh et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 47(2), 82-90 (2002-03-20)
The aims of the present study were to (i) determine the presence and concentration of albumin fractions (alpha1, alpha2, beta, gamma), immunoglobulins (IgA, IgG, IgM) and cytokines [interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF)] in periovulatory ovarian follicular fluid (FF)
Seung Hyun Kim et al.
Bioorganic & medicinal chemistry letters, 20(9), 2824-2827 (2010-04-07)
The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and
E Pospísilová et al.
Journal of inherited metabolic disease, 26(5), 433-441 (2003-10-02)
Two methods, spectrophotometry and HPLC, were compared in the analyses of 3-hydroxy-3-methylglutaryl-CoA lyase (HL) activity in three unrelated Czech patients with 3-hydroxy-3-methylglutaric (HMG) aciduria and their family members. The HL activities in cultured fibroblasts and/or isolated lymphocytes of probands were
Núria Casals et al.
The Journal of biological chemistry, 278(31), 29016-29023 (2003-05-15)
This study describes three novel homozygous missense mutations (S75R, S201Y, and D204N) in the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase gene, which caused 3-hydroxy-3-methylglutaric aciduria in patients from Germany, England, and Argentina. Expression studies in Escherichia coli show that S75R and S201Y substitutions
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