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Dokumente

ALD00550

Serine Hydrolase Inhibitor-17

Name: Serine Hydrolase Inhibitor-17
Brand: ALDRICH

Synonym(e):

tert-Butyl 4-(1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate, SHI-17

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About This Item

Empirische Formel (Hill-System):

C₁₄H₂₂N₄O₃

CAS-Nummer:

1622426-20-3

Molekulargewicht:

294.35

UNSPSC-Code:

12352200

PubChem Substanz-ID:

329772714

NACRES:

NA.22

Form

solid

Qualitätsniveau

100

SMILES String

O=C(N1CCCN(C(OC(C)(C)C)=O)CC1)N2N=CC=C2

InChI

1S/C14H22N4O3/c1-14(2,3)21-13(20)17-8-5-7-16(10-11-17)12(19)18-9-4-6-15-18/h4,6,9H,5,7-8,10-11H2,1-3H3

InChIKey

SREDUUSCWDQNQK-UHFFFAOYSA-N

Anwendung

Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine hydrolase class of proteins. They are amenable to further modification to create novel inhibitors of this class of protein.

Piktogramme

GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P330 + P331 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Discovery libraries targeting the major enzyme classes: the serine hydrolases.

Katerina Otrubova et al.

Bioorganic & medicinal chemistry letters, 24(16), 3807-3813 (2014-07-20)

Two libraries of modestly reactive ureas containing either electron-deficient acyl anilines or acyl pyrazoles were prepared and are reported as screening libraries for candidate serine hydrolase inhibitors. Within each library is a small but powerful subset of compounds that serve

Verwandter Inhalt

Boger Group – Professor Product Portal

As the exploration of the properties of complex natural products becomes increasingly more sophisticated with the technological advances being made in their screening and evaluation and as structural details of their interaction with biological targets becomes more accessible, the importance and opportunities for providing unique solutions to complex biological problems has grown. The Boger Lab addresses these challenging problems by understanding the complex solutions and subtle design elements that nature has provided in the form of a natural product and work to extend the solution through rational design elements to provide more selective, more efficacious, or more potent agents designed specifically for the problem or target under investigation. The resulting efforts have reduced many difficult or intractable synthetic challenges to manageable problems providing an approach not only to the natural product but one capable of simple extrapolation to a series of structural analogs with improved selectivity and efficacy.

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