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Merck

930024

Sigma-Aldrich

Hyaluronic acid adipic dihydrazide (HA-ADH)

Synonym(e):

HA-ADH

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About This Item

Lineare Formel:
(C20H33N5O12)n
UNSPSC-Code:
12352125
NACRES:
NA.23

Form

solid (Chunks)

Qualitätsniveau

Farbe

white to off-white

Anwendung(en)

3D bioprinting

Lagertemp.

2-8°C

Allgemeine Beschreibung

Adipic acid dihydrazide is commonly used as a functional group to allow for HA cross-linking to polymers containing aldehyde groups or that are aldehyde-functionalized, like HA-aldehyde or PEG-aldehyde. These biomaterials are attractive for their tunable properties and low cytotoxicity.
Degree of functionalization (50-80%)

Anwendung

Hyaluronic acid (HA) is a ubiquitous extracellular matrix component, which makes it attractive for use in medical applications for it′s biocompatibility and low immunogenicity. HA-based polymers are used to make hydrogels for a wide variety of applications from tissue engineering and regeneration to drug delivery and bioinks for 3D bioprinting. To make hydrogels, HA has to be derivatized with groups that can cross-link to to other functionalized polymers.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Synthetic hydrogel scaffolds that can be used as culture systems that mimic the natural stem cell niche are of increased importance for stem cell biology and regenerative medicine. These artificial niches can be utilized to control the stem cell fate
Xinqiao Jia et al.
Biomacromolecules, 7(12), 3336-3344 (2006-12-13)
Vocal fold scarring disrupts the viscoelastic properties of the lamina propria that are critical for normal phonation. There is a clinical need for the development of advanced biomaterials that approximate the mechanical properties of the lamina propria for in vivo

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