924113

Amine-a-TCO

• Synonym(e): (R,E)-1-(2-Aminoethyl)cyclooct-4-en-1-ol, 5-ax-Hydroxy-5-eq-(2-aminoethyl)-trans-cyclooctene
• Empirische Formel (Hill-System): C₁₀H₁₉NO
• Molekulargewicht: 169.26
• UNSPSC-Code: 12352200

Eigenschaften

• Form: powder or solid (or chunks)
• Qualitätsniveau: 100
• Farbe: white to light yellow
• Lagertemp.: −20°C

Beschreibung

Anwendung

Amine-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. Amine-a-TCO has an acid-reactive terminal amine, and the a-TCO reacts rapidly with tetrazines through Diels–Alder reactions, a type of bioorthogonal, copper-free click chemistry. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more reactive and hydrophilic than standard TCOs, providing favorable physiochemical properties for live-cell and in vivo labeling.
Other new a-TCOs:

• NHS ester-a-TCO (924075)
• TAMRA-a-TCO (924083)
• Alkyne-a-TCO (924113)

Sonstige Hinweise

General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable