907197

1,4-Dinitro-1-imidazole

• Synonym(e): 1,4-DNIm, 1,4-Dinitroimidazole, Bifunctional bioconjugation reagent
• Empirische Formel (Hill-System): C₃H₂N₄O₄
• CAS-Nummer: 19182-81-1
• Molekulargewicht: 158.07
• MDL-Nummer: MFCD00297235
• UNSPSC-Code: 12352005

Eigenschaften

• Assay: ≥95%
• Form: solid
• Lagertemp.: −20°C
• InChI: 1S/C3H2N4O4/c8-6(9)3-1-5(2-4-3)7(10)11/h1-2H
• InChIKey: HZPSREFSUPXCMN-UHFFFAOYSA-N

Beschreibung

Anwendung

1,4-Dinitro-1-imidazole (1,4-DNIm) and other dinitroimidazoles were demonstrated to be bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. In acidic to neutral aqueous conditions, 1,4-DNIms chemoselectively react with cysteines; in organic solvents in the presence of base, 1,4-DNIms chemoselectively react with lysines to form stable conjugates

Sonstige Hinweise

Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable