748684

Phosgen -Lösung

15 wt. % in toluene

• Synonym(e): Carbon oxychloride, Carbonyl chloride, Phosgen
• Lineare Formel: COCl₂
• CAS-Nummer: 75-44-5
• Molekulargewicht: 98.92
• Beilstein: 1098367
• MDL-Nummer: MFCD00036119
• UNSPSC-Code: 12352101
• PubChem Substanz-ID: 329765925
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Qualitätsniveau: 200
• Konzentration: 15 wt. % in toluene
• Dichte: 0.924 g/mL at 25 °C
• Lagertemp.: 2-8°C
• SMILES String: ClC(Cl)=O
• InChI: 1S/CCl2O/c2-1(3)4
• InChIKey: YGYAWVDWMABLBF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.

Anwendung

Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:

• γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
• 2-nitrobenzyl(4-vinylphenyl)carbamate

Phosgene solution may be used in the synthesis of:

• sulfonyl chlorides
• Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
• O-benzyl-L-serine carboxyanhydrides

Verpackung

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Rechtliche Hinweise

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08,GHS05
• Signalwort: Danger
• H-Sätze: H225,H304,H314,H330,H336,H361d,H373,H412
• P-Sätze: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 39.2 °F - closed cup
• Flammpunkt (°C): 4 °C - closed cup